|
KMID : 0371420140860060302
|
|
Annals of Surgical Treatment and Research
2014 Volume.86 No. 6 p.302 ~ p.308
|
|
|
Relationship between 15-hydroxyprostaglandin dehydrogenase and gastric adenocarcinoma
|
|
Kang Jae-Hyun
Kang Sang-Hyun
Seo Sang-Hyuk
Shin Jae-Ho
An Min-Sung
Ha Tae-Kwun
Bae Ki-Beom
Kim Tae-Hyun
Choi Chang-Soo
Oh Sang-Hoon
Kang Mi-Seon
Kim Kwang-Hee
|
|
|
Abstract
|
|
|
Purpose: Prostaglandin E2 (PGE2) is a contributory carcinogen in gastric adenocarcinoma. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catabolizes PGE2 by oxidizing its 15(s)-hydroxy group. The aim of this study was to investigate the expression of 15-PGDH in gastric adenocarcinoma tissue and the relationship between 15-PGDH expression and clinicopathologic features of gastric adenocarcinoma.
Methods: Ninety-nine patients who underwent surgical resection for gastric adenocarcinoma between January 2007 and December 2007 were enrolled and evaluated retrospectively.
Results: In 62 patients (62.6%), 15-PGDH expression was lower in gastric adenocarcinoma tissue than in nonneoplastic tissue. Regarding the relationship between 15-PGDH expression and clinicopathological features, 15-PGDH expression was significantly lower in tissues with poor differentiation (P = 0.002), advanced T stage (P = 0.0319), a higher number of lymph node metastases (P = 0.045), lymphatic invasion (P = 0.031), and vascular invasion (P = 0.036).
Conclusion: 15-PGDH expression was associated with a subset of clinicopathologic features such as differentiation grade, T stage, lymphatic invasion, and vascular invasion.
|
|
|
KEYWORD
|
|
|
Gastric neoplasms, 15-Hydroxyprostaglandin dehydrogenase, Differentiation, Staging
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|